Had a great lunch here on a business trip.  It may be a little off your path, but not far from the Philly Turnpike.  I had one of the best crab cake sandwiches I have ever had here, and that was even after having them in Baltimore at the hyped-up places.  Salad, soup, all was great here;
http://www.sunnysiderestaurant.com http://www.sunnysiderestaurant.com/
 
 

I had a good meal here, and lots of old local photos, etc. on the walls:
 
[h1]Tony’s Cottage Inn[/h1] Rr 322 Box W, Lewistown, PA

I’ll take any and all suggestions for a lunch place or nice stop on Route 80 between PHL and Cleveland

There are a number of Truckstops along the Interstate. They’re generally pretty good. There’s a TA at the Brookville PA Exit that’s pretty good.

The Clem’s in Port Matilda closed as a casualty of the new highway. There’s another one in a retail space in State College but it definitely doesn’t have the same atmosphere.

Man.
 
Denny’s Beer Barrel Pub in Clearfield. Famous burgers. Not awesome, but OK.
 

 

 
 
Gio’s, also in Clearfield, one exit east of Denny’s. Very interesting, needs more exploring.
 

 

 

 
 
Near State College, Clem’s BBQ. I haven’t been, but it smells real. On 322 in Port Matilda.
 

 
 
 
I imagine your route involves 476 north to White Haven? The White Haven Diner. joerogo has a picture somewhere. edit: Found it; that’s jr’s shot of the burger.
 
    
 
 
 
 
 
 
 

Do you mean INTERSTATE 80?