There were probably hundreds of regional beers at one time. My grandfather began working in the accounting dept. at Buckeye Brewing in Toledo, OH. when he was 16 (which would have 1902). When he retired
in 1955, he was president of the company. During that whole period (and after) Buckeye was simply a regional beer distributed in NW Ohio and SE Michigan. I don’t think they even made it as far as Cleveland.
I never saw him drink anything but Buckeye. In fact, my dad once developed a taste for an ale (green bottles, brewed in upstate NY) whose name escapes me at this time and brought a case home. My grandfather didn’t speak to him until that case was gone. In any event, Buckeye kept going until the mid to late 60’s and then they were purchased by Miller. I think Miller kept the brand alive for a couple of years, but Buckeye eventually disappeared. That was probably very much the fate of a lot of regional beers, if they were lucky enough to get purchased and not simply driven out of the market by a major brand.